Andrew Walsh1, Marguerite Wieler2,
Wayne Martin2, Alan Wilman1
1Biomedical Engineering, University of
Alberta, Edmonton, Alberta, Canada; 2Division of Adult Neurology,
University of Alberta, Edmonton, Alberta, Canada
We
examined the effectiveness of current methods in susceptibility phase imaging
of basal ganglia structures using computer simulations and invivo data. The
effects of phase filtering reconstruction, slice orientation and ROI
selection with comparison to T2* mapping are examined in this study. These investigations showed that measured
phase can be substantially influenced by filtering, slice orientation and ROI
selection which can confound phase data acquired in cross sectional or
longitudinal studies. We have proposed
techniques to optimize phase value acquisition for the consistent evaluation
of phase in future studies.
Keywords