Brian Keating1, Weiran Deng1, J
Cooper Roddey2, Nathan White3, Anders Dale2,
V Andrew Stenger1, Thomas Ernst1
1Department of Medicine, University of
Hawaii, Honolulu, HI, United States; 2Department of Neuroscience, University
of California at San Diego, La Jolla, CA, United States; 3Department
of Cognitive Science, University of California at San Diego, La Jolla, CA,
United States
Motion
during brain 1H MR spectroscopy acquisitions can compromise
spectral quality. We adapted an image-based adaptive motion correction module
for use with a PRESS sequence. Sets of three orthogonal spiral navigator
images are acquired in each TR period, to estimate head motion in
real-time. By applying the appropriate
rotations and translations, the voxel can be made to remain stationary with
respect to the brain. Adaptive motion correction recovered original
metabolite values (Cho/Cr ratio) to within a few percent even for extensive
head movements (20-30), whereas non-navigated spectra showed marked changes
in metabolite levels as well as increased variability.