Robert Merwa1, Gernot Reishofer2, Thorsten Feiweier3, Karin Kapp4, Franz Ebner2, Rudolf Stollberger5
1Medical Engineering, FH O - Upper Austria University of Applied Sciences, Linz, Austria; 2Department of Radiology, Medical University of Graz, Graz, Austria; 3Healthcare, Siemens AG, Germany; 4Department of Radiation Therapy, Medical University of Graz, Graz, Austria; 5Institute of Medical Engineering, Graz University of Technology, Graz, Austria
Dynamic contrast-enhanced MRI was performed at 3 T in combination with a flip angle mapping sequence in order to correct the kinetic parameters of human tissue. Due to the local magnitude of these inhomogenities the values for the AIF and tissue concentrations are widespread which lead to an overestimation or underestimation of Ktrans and Ve. The peak of the arterial input function decreases of about 60 % and the absolute difference of Ktrans and Ve obtained with the AIF in two comparable arteries can be improved by a factor up to 33 if the dynamic data are corrected accordingly.