Robert Merwa1,
Gernot Reishofer2, Thorsten Feiweier3, Karin Kapp4,
Franz Ebner2, Rudolf Stollberger5
1Medical Engineering, FH O - Upper
Austria University of Applied Sciences, Linz, Austria; 2Department
of Radiology, Medical University of Graz, Graz, Austria; 3Healthcare,
Siemens AG, Germany; 4Department of Radiation Therapy, Medical
University of Graz, Graz, Austria; 5Institute of Medical
Engineering, Graz University of Technology, Graz, Austria
Dynamic
contrast-enhanced MRI was performed at 3 T in combination with a flip angle
mapping sequence in order to correct the kinetic parameters of human tissue.
Due to the local magnitude of these inhomogenities the values for the AIF and
tissue concentrations are widespread which lead to an overestimation or
underestimation of Ktrans and Ve. The peak of the
arterial input function decreases of about 60 % and the absolute difference
of Ktrans and Ve obtained with the AIF in two
comparable arteries can be improved by a factor up to 33 if the dynamic data
are corrected accordingly.
Keywords