Zhengyi Yang1, Viktor Vegh1,
Deming Wang1, David Charles Reutens1,2
1University of Queensland, Brisbane,
Queensland, Australia; 2Royal Brisbane and Women's Hospital,
Brisbane, Queensland, Australia
Registration
of histological sections and the corresponding MR images is a critical step
in MR constrained histology volume reconstruction. Histological sections with
dislocated segments are problematic. This issue is addressed by employing a
local rigid registration method. The dislocated segments are identified by
morphological operations and connectivity analysis. These segments are
treated as rigid bodies having independent degree-of-freedom of motion. The
registration was to find the transformation matrix for each segment to
maximize the similarity, which was normal mutual information, between the
transformed histological section and target MR image. The method of
differential evolution was used to find optimal registrations.