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Abstract #5106

Texture Analysis of MRI of Juvenile Myoclonic Epilepsy Patients

Mrcia Silva de Oliveira1,2, Luiz Eduardo Betting, 23, Fernando Cendes, 23, Gabriela Castellano1,2

1Neurophysics Group, State University of Campinas (Unicamp), Campinas, SP, Brazil; 2CInAPCe (Cooperao Interinstitucional de Apoio a Pesquisas sobre o Crebro), So Paulo State, Brazil; 3NeuroImage Laboratory, State University of Campinas (Unicamp), Campinas, SP, Brazil

Juvenile myoclonic epilepsy (JME) is the most frequent subsyndrome of the idiopathic generalized epilepsies. Experimental investigations support that the thalamus is a key structure in the mechanisms of JME. The objective of this study was to investigate the thalamus of patients with JME using texture analysis, a quantitative neuroimaging technique. Patients and controls were submitted to MRI investigation. The T1 volumetric sequence was used for thalamic segmentation and extraction of texture parameters. Texture analysis revealed differences between the thalamus of patients and controls. The present investigation supports the participation of the thalamus in the mechanisms of JME.