Abstract #0029

Prognostic Value of 1H-MRS & DTI after Hypothermic Treatment in Newborns with Perinatal Asphyxial Encephalopathy

Claudia Testa¹, Caterina Tonon¹, David Neil Manners¹, Emil Malucelli¹, Sara Grandi², Francesca Sbravati², Giacomo Faldella², Gina Ancora², Raffaele Lodi¹

¹MR Spectroscopy Unit, Department of Internal Medicine, Aging & Nephrology, University of Bologna, Bologna, Italy; ²Neonatology Unit, Department of Woman, Child & Adolescent Health, University of Bologna, Bologna, Italy

¹-MRS and DTI were evaluated in 19 neonates with hypoxic-ischemic encephalopathy after brain cooling. MRS was acquired in the basal ganglia, in white and gray matter; DTI was acquired using 15 gradient directions. Metabolites ratios and concentrations, MD and FA maps were calculated. ROIs were semi-automatically drawn onto each FA and MD map using study specific templates.