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Abstract #0029

Prognostic Value of 1H-MRS & DTI after Hypothermic Treatment in Newborns with Perinatal Asphyxial Encephalopathy

Claudia Testa1, Caterina Tonon1, David Neil Manners1, Emil Malucelli1, Sara Grandi2, Francesca Sbravati2, Giacomo Faldella2, Gina Ancora2, Raffaele Lodi1

1MR Spectroscopy Unit, Department of Internal Medicine, Aging & Nephrology, University of Bologna, Bologna, Italy; 2Neonatology Unit, Department of Woman, Child & Adolescent Health, University of Bologna, Bologna, Italy

1-MRS and DTI were evaluated in 19 neonates with hypoxic-ischemic encephalopathy after brain cooling. MRS was acquired in the basal ganglia, in white and gray matter; DTI was acquired using 15 gradient directions. Metabolites ratios and concentrations, MD and FA maps were calculated. ROIs were semi-automatically drawn onto each FA and MD map using study specific templates.