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Abstract #0030

Serial Diffusion Tensor Tractography Studies in Term Neonates with Hypoxic Ischemic Encephalopathy

Richa Trivedi1, Abhishek Yadav2, Gyanendra Kumar Malik3, Archana Yadav3, Ram K. S. Rathore4, Rakesh Kumar Gupta2

1Institute of Nuclear Medicine & Allied Sciences, New Delhi, Uttar Pradesh, India; 2Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 3Paediatrics, Chhatrapati Sahu ji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 4Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India

Serial diffusion tensor tractography using FACT algorithm was performed on 11 term neonates with moderate hypoxic ischemic encephalopathy (HIE) to look for the change over time of the DTI measures in thalamic radiations in these infants compared to age/sex matched healthy controls through their early infancy. On comparing FA and MD changes over time, we observed altered patterns of age-related FA increase and MD decrease in thalamic radiations in neonates with HIE compared with controls. Our study suggests that abnormal FA and MD values with near normal conventional imaging may allow early and more accurate assessment of injury in neonates with HIE.