Abstract #0076

AxCaliber 3D

Daniel Barazany¹, Derek Jones², Yaniv Assaf¹

¹Neurobiology, Tel Aviv University, Tel Aviv, Israel; ²CUBRIC, School of Psychology, Cardiff University, Wales, UK

So far, the ability to map the axon diameter distribution (ADD) along a given pathway was only possible with AxCaliber if the fiber orientation was known and so this precludes any tract-specific assessment. We extended the AxCaliber framework to 3D, and were able to achieve the ADD in any voxel of the brain and any fiber orientation. In the work, we analyzed the two main fiber fascicles of the porcine spinal cord which are known to have different ADDs. AxCaliber was able to distinguish between them and calculate their ADDs.