Wei Li1, Bing Wu1, Chunlei Liu1,2
1Brain Imaging & Analysis Center, Duke University, Durham, NC, USA; 2Radiology, Duke University, Durham, NC, USA
Previously, the magnetic susceptibility of brain tissue is generally assumed to be isotopic. Recently, emerging evidences from animal studies and in vitro brain specimens started to show the directionality of susceptibility. In this study, we demonstrated the evidence of magnetic susceptibility anisotropy from in vivo human brain by comparing susceptibility map with the diffusion tensor imaging results and comparing susceptibility obtained from different orientations. Further, the susceptibility tensor is calculated, which shows varied gray and white matter contrast among the three principal eigenvalues. These results provide convincing evidences that the magnetic susceptibility of in vivo human brain is anisotropic.