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Abstract #0122

Origin of Phase Contrast: Insight from Susceptibility, R2* & Element Imaging by LA-ICP-MS

Ana-Maria Oros-Peusquens1, Andreas Matusch2, Johannes Lindemeyer3, Sabine Johanna Becker4, Nadim Jon Shah1

1Institute of Neuroscience & Medicine (INM-4), Research Centre Juelich, Juelich, NA, Germany; 2INM-2, Research Centre Juelich, Germany; 3INM-4, Research Centre Juelich, Germany; 4ZCH, Research Centre Juelich

MR-based maps of susceptibility, field and R2* distribution were compared to element imaging using Laser Ablation Inductively Coupled Mass Spectrometry (LA-ICP-MS). The distributions of carbon (C) and iron (Fe), elements thought to be the main determinants of susceptibility and phase contrast, show much more detail than the susceptibility and field maps obtained from MRI. A linear dependence between R2* and Fe concentration has been confirmed in a limited, ROI-based analysis. A clustering analysis of the distribution of 15 elements shows features which are unclear in the phase or susceptibility distributions but can be found in the mixed-contrast T2*-weighted high-resolution images.