Sandeep Ganji1, Ralph De Berardinis1, Zoltan Kovacs1,
Robert Bachoo1, Juan Pascual1, Ivan Dimitrov1,2,
Bruce Mickey1, Craig Malloy1,3,
Recent studies indicate that a high fraction of gliomas contain mutations in the metabolic enzymes, isocitrate dehydrogenase-1 and -2, IDH1 and IDH2. As a result, 2-hydroxyglutarate (2HG), which is normally present in vanishingly small quantities, can be elevated by orders of magnitude in gliomas bearing IDH1 or IDH2 mutations. Here, we report for the first time in vivo detection of this oncometabolite in human brain tumors by 1H-MRS at 3T. 2HG was detected with CRLB < 20% in 38 spectra out of 122 spectra from 49 tumor patients (29 GBM, 9 anaplastic astrocytoma, and 11 low-grade glioma), the concentrations being 2 - 8 mM.