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Abstract #0182

Metabolic Characterization of Glioma Populations with Emphasis on Onco-Metabolite 2-Hydroxyglutarate

Adam Elkhaled1, Llewellyn Jalbert1, Hikari Yoshihara1, Gabriella Bourne1, Joanna Phillips2, Soonmee Cha1, Susan M. Chang3, Radhika Srinivasan1, Sarah J. Nelson1,4

1Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; 2Department of Pathology, University of California, San Francisco; 3Department of Neurological Surgery, University of California, San Francisco; 4Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco

Low grade gliomas with mutations in the isocitrate dehydrogenase-1 (IDH1) gene carry a significant survival advantage, and have recently been shown to manifest excessive production of 2-hydroxyglutarate (2HG). Given the potential prognostic value of 2HG as an onco-metabolite, we sought to characterize differences in metabolite levels between gliomas of distinct origin and grade using