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Abstract #0229

New MRI Contrasts in Experimental Stroke: What Do We Measure with RAFF & ZAPI?

Johanna Nrvinen1, Kimmo Jokivarsi2, Timo Liimatainen, Olli Grhn, Risto A. Kauppinen3

1A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland; 2Massachusetts General Hospital; 3Dartmouth College, USA

Recently introduced MRI techniques, RAFF and ZAPI, were used to study acute stroke in a rat model. It is concluded that 1) Relaxation and MT are not coupled in acute cerebral stroke, even when clean on-resonance ZAPI-MT is used. 2) RAFF signal is sensitive to ischemia with sensitivity and temporal behavior comparable to T2, but inferior to T. 3) RAFF signal change in ischemic tissue can be predicted by simulations. 4) On resonance-MT differs from off-resonance MT, both in magnitude and in temporal evolution during stroke.