Abstract #0230

Observation of Myelin Water at Ultra-Short Echo Time by Longitudinal Relaxographic Imaging with Spin-Echo Center-Out EPI (DEPICTING)

Christian Labadie^1,2, William D. Rooney³, Charles S. Springer, Jr.³, Jing-Huei Lee⁴, Monique Aubert-Frcon², Stefan Hetzer⁵, Toralf Mildner¹, Harald E. Mller¹

¹Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany; ²Laboratoire de Spectromtrie Ionique et Molculaire, Universit Claude Bernard Lyon 1, France; ³Oregon Health & Science University, Portland, OR, USA; ⁴Biomedical Engineering, University of Cincinnati, OH, USA; ⁵Bernstein Center for Computational Neuroscience, Berlin, Germany

We adapted a spin-echo center-out echo planar imaging with ultra-short echo time [TE] (DEPICTING) pulse sequence with an inversion recovery [IR] preparation. Two series of 32 pseudo-randomized TIs were acquired with two TEs and analyzed by cross-regularized inverse Laplace transform. The human white matter water proton T2 value associated with the short component w. small water proton T1 detected by IR relaxographic analysis was determined to be 34.2 ms and supports its the assignment as a myelin water fraction.