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Abstract #0230

Observation of Myelin Water at Ultra-Short Echo Time by Longitudinal Relaxographic Imaging with Spin-Echo Center-Out EPI (DEPICTING)

Christian Labadie1,2, William D. Rooney3, Charles S. Springer, Jr.3, Jing-Huei Lee4, Monique Aubert-Frcon2, Stefan Hetzer5, Toralf Mildner1, Harald E. Mller1

1Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany; 2Laboratoire de Spectromtrie Ionique et Molculaire, Universit Claude Bernard Lyon 1, France; 3Oregon Health & Science University, Portland, OR, USA; 4Biomedical Engineering, University of Cincinnati, OH, USA; 5Bernstein Center for Computational Neuroscience, Berlin, Germany

We adapted a spin-echo center-out echo planar imaging with ultra-short echo time [TE] (DEPICTING) pulse sequence with an inversion recovery [IR] preparation. Two series of 32 pseudo-randomized TIs were acquired with two TEs and analyzed by cross-regularized inverse Laplace transform. The human white matter water proton T2 value associated with the short component w. small water proton T1 detected by IR relaxographic analysis was determined to be 34.2 ms and supports its the assignment as a myelin water fraction.