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Abstract #0233

Three Dimensional T2prep Spiral Imaging with Efficient Brain Coverage For Myelin Water Quantification: Validation At 1.5 Tesla

Thanh D. Nguyen1, Cynthia Wisnieff2, Mitchell Cooper2, Dushyant Kumar1, Ashish Raj1, Martin R. Prince1, Yi Wang1, Tim Vartanian3, Susan A. Gauthier3

1Radiology, Weill Cornell Medical College, New York, NY, USA; 2Biomedical Engineering, Cornell University, Ithaca, NY, USA; 3Neurology, Weill Cornell Medical College, New York, NY, USA

The objective of this study was to develop and optimize an SNR efficient 3D T2prep spiral gradient echo sequence for full brain T2 relaxometry and to validate this sequence using 3D FSE as reference standard at 1.5T. The spiral sequence was found to provide similar T2 on phantom and myelin water fraction for various brain tissues. 28 axial slices and 24 T2prep times can be obtained in 24 min with 2.5-fold higher SNR than conventional 2D FSE approach.