Abstract #0303

SPECT Validation of Pseudo-Continuous Arterial Spin Labeling MRI

Peiying Liu¹, Jinsoo Uh¹, Michael D. Devous², Bryon Adinoff^3,4, Hanzhang Lu¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; ²Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; ³Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; ⁴VA North Texas Health Care System, Dallas, TX, USA

Pseudo-continuous Arterial Spin Labeling (PCASL) as a new arterial spin labeling (ASL) technique has shown great promises in terms of sensitivity and practicality. Validation of this technique with a gold-standard method would provide a critical step toward wider applications in neurological and brain mapping studies. Here we first determined the arterial transit times which are important in the quantification of CBF from ASL signals by measuring the time difference between the appearance of Gd-DTPA bolus in the labeling and imaging slices, respectively. We then conducted a validation study of PCASL using a radiotracer-based single photon emission computer tomography (SPECT) method.