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Abstract #0412

Surface Based Analysis of Diffusion Orientation for Identifying Architectonic Domains in the In Vivo Human Cortex

Jennifer Andrea McNab1, Jonathan R. Polimeni1, Lawrence L. Wald1,2

1A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 2Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

We present a surface-based analysis that characterizes the principal diffusion eigenvectors from 1 mm isotropic diffusion measurements relative to the cortical surface normal. We investigate DTI changes as a function of cortical depth, surface curvature and partial volume effects. We find that much of the cortex is predominately radial, but replicate the finding that S1 cortex is strongly tangential. Cortical regions S2 and A1 share S1s tangential orientation. The ability to parcellate folded cortex by diffusion metrics provides new possibilities for studying brain organization as it relates to function in the healthy and diseased brain.