Abstract #0413

Multi-TE Diffusion Tensor Imaging In Vivo

Alexandru Vlad Avram^1,2, Arnaud Guidon^1,2, Chunlei Liu², Allen W. Song²

¹Biomedical Engineering Department, Duke University, Durham, NC, USA; ²Brain Imaging & Analysis Center, Duke University Medical Center, Durham, NC, USA

We investigate the echo time (TE) dependence of white matter diffusion anisotropy using a novel stimulated echo based (STE) self-navigated interleaved spiral (SNAILS) DTI sequence capable of imaging with a wide range of TEs (22 82 ms) while maintaining adequate b-value (600 s/mm2). We quantify the dependence of FA, axial and radial diffusivities on TE for the first time with an in vivo experiment and present a clinical subtraction-based technique for achieving short T2 (myelin) specificity by acquiring DTI datasets at only two TEs.