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Abstract #0468

Potential of Relaxation-Weighted 23Na-MRI for Brain Tumor Characterization

Armin Michael Nagel1, Michael Bock1, Christian Hartmann2, Lars Gerigk1, Jan-Oliver Neumann2, Marc-Andr Weber2, Martin Bendszus2, Alexander Radbruch2, Wolfgang Wick2, Heinz-Peter Schlemmer1, Wolfhard Semmler1, Armin Biller2

1German Cancer Research Center, Heidelberg, Germany; 2University Hospital Heidelberg, Germany

In this work 16 patients suffering from different brain tumors (14 WHO grade I IV and 2 metastases) were examined, to evaluate if relaxation-weighted 23Na-MRI can provide information for tumor grading. All glioblastomas (WHO grade IV) showed higher signal intensities in relaxation-weighted imaging than the WHO grad I - III tumors. Regression analysis yielded a positive correlation between the relaxation-weighted 23Na-MRI signal and the MIB-1 proliferation rate, a histological tumor marker. No correlation was found for the total 23Na-signal.