Yosuke Otake1, Koji Hirata1, Yoshihisa Soutome1, Yoshitaka Bito1
Central Resaerch Laboratory, Kokubunji,
A 19F two-element phased-array coil with a transmit 19F/1H dual-tuned linear-birdcage coil for rats was developed. In-vivo 19F imaging of the anticancer drug 5-Fluorouracil and its metabolites in tumor-bearing rats was demonstrated by using the developed coils. Time courses of 5-FU and its active-metabolite (Fnuc) distribution images were obtained in the region of the tumor by using fast spin echo with frequency-selective pulses. This study indicates that the developed 19F two-element phased-array coil will make small-animal studies possible in drug research.