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Abstract #0477

In-Vivo 19F Imaging of 5-Fluorouracil & its Metabolites in Rat by Two-Element Phased-Array Coil

Yosuke Otake1, Koji Hirata1, Yoshihisa Soutome1, Yoshitaka Bito1

1Hitachi, Ltd., Central Resaerch Laboratory, Kokubunji, Tokyo, Japan

A 19F two-element phased-array coil with a transmit 19F/1H dual-tuned linear-birdcage coil for rats was developed. In-vivo 19F imaging of the anticancer drug 5-Fluorouracil and its metabolites in tumor-bearing rats was demonstrated by using the developed coils. Time courses of 5-FU and its active-metabolite (Fnuc) distribution images were obtained in the region of the tumor by using fast spin echo with frequency-selective pulses. This study indicates that the developed 19F two-element phased-array coil will make small-animal studies possible in drug research.