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Abstract #0505

Parametric Relaxation Measurements in Bovine Patellar Cartilage

Wen Ling1, Elizabeth Arendt2, Denis Clohisy2, Silvia Mangia1, Shalom Michaeli1, Michael Garwood1, Jutta Elllermann1

1Center for Magnetic Resonance Research, Univ. of Minnesota, Minneapolis, MN, USA; 2Dept. of Orthopedic Surgery, Univ. of Minnesota, Minneapolis, MN, USA

Bovine patellar cartilage plugs with trypsin treatment (n=4) were used to compare various contrast mechanisms, including T2, T1ρ by adiabatic HS1 and HS4 modulation, RAFF (relaxation along a fictitious field), and MT (magnetic transfer). Each of the plugs was scanned twice: before and after trypsin treatments. The control group (n=4) were through the same process except without trypsin treatment. Our results not only depict that adiabatic T1ρ gives rise to high sensitivity to proteoglycan induced change in cartilage, but also indicate it is a robust and artifact-free method.