Xiaojuan Li1, Joseph Schooler1, Fei Liang1, Keerthi Shet Vishnudas1, Weitian Chen2, Suchandrima Banerjee2, Sharmila Majumdar1
1Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA
Magnetic resonance (MR) T1ρ and T2 relaxation time quantification can detect biochemical changes within cartilage collagen/proteoglycan matrix, and may provide complementary information associated with cartilage degeneration during osteoarthritis (OA). These techniques, however, normally need a long acquisition time. Furthermore, few studies have explored the potential diurnal variation in cartilage. The goals of this study were three fold: 1) To develop a sequence that combines T1ρ and T2 quantification; 2) To examine intra-day and inter-day reproducibility of the T1ρ and T2 quantification; 3) To examine the potential diurnal variation of T1ρ and T2 quantification in cartilage in young healthy adults.