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Abstract #0523

Pressure & Microbubble-Size Dependence of the FUS-Induced Blood Brain Barrier Opening Reversibility In Vivo

Gesthimani Samiotaki1, Yao-Sheng Tung1, Fotios Vlachos1, Elisa Konofagou1,2

1Department of Biomedical Engineering, Columbia University, New York, NY, USA; 2Department of Radiology, Columbia University, New York, NY, USA

The purpose of this study was to use CE-T1 weighted MR imaging to evaluate the reversibility of focused ultrasound-induced blood-brain barrier opening in vivo, and its dependence on the acoustic pressures and microbubble sizes used. Duration and volume of the opening region were found to increase with pressure amplitude and microbubble diameter. The shortest opening duration was (24hours) at 1-2μm microbubbles and 0.45MPa, and the longest was (5 days) at 4-5μm and 6-8μm and 0.60MPa. In most cases no histological damage was noted, when it was, it was found to be highly correlated with residual gadodiamide in the opening area.