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Abstract #0532

Measuring the Volumes & Thickness of Hippocampal Subfields In Vivo using Automatic Segmentation of T2-Weighted MRI: A Pilot Evaluation Study

Paul A. Yushkevich1, Hongzhi Wang1, John Pluta1, Sandhitsu R. Das1, Brian Avants1, Michael Weiner2, Susanne Mueller2, David Wolk3

1PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Department of Radiology, University of California, San Francisco, San Francisco, CA, USA; 3Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA

High-resolution T2-weighted MRI has been shown to be a promising modality for imaging the subfields of the hippocampal formation. However, until now, the analysis of this data required tedious manual segmentation. We present a reliable method for automatic segmentation of hippocampal subfields in T2-weighted MRI and apply it to measure group differences in subfield volume and thickness between amnestic MCI patients and controls.