Shawn Sidharthan1, Ryan Joseph Hutten1, Christopher Glielmi2, Hongyan Du3, Fiona Malone1, Ann Ragin1,4, Robert R. Edelman1, Ying Wu1,5
1Radiology, NorthShore University HealthSystem, Evanston, IL, USA; 2MR Research & Development, Siemens Healthcare, Chicago, IL, USA; 3Center for Clinical Research Informatics, NorthShore University HealthSystem, Evanston, IL, USA; 4Radiology, Northwestern University, Chicago, IL, USA; 5Radiology, University of Chicago, Chicago, IL, USA
Magnetization transfer ratio (MTR) may detect subtle microscopic changes in the hippocampus before macroscopic anomalies occur. This modality proves to be a crucial tool when evaluating patients with progressive neurological pathologies such as Alzheimers disease. In this study, reliability and reproducibility were analyzed for high-resolution MTR at 3T in different metrics (mean and histogram approach) and compared to the more conventional MR volumetric method in the hippocampus. Mean and histogram MTR approach derived from automated post-processing methods, provided excellent scan-rescan results in comparison to volumetry. The results indicate MTR and volumetric analysis to be a useful tool for future studies.