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Abstract #0534

Analysis of Hippocampal Shape in Children using a Surface-to-Centerline Distance Method & Template-Based Surface & Volumetric Non-Rigid Registration Methods

Muqing Lin1, Kevin Head2, Claudia Buss2, Tugan Muftuler1, Elysia Poggi Davis1, Curt A. Sandman2, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Tu & Yuen Center for Functional Onco-Imaging & Department of Radiological Sciences, University of California, Irvine, CA, USA; 2Department of Psychiatry & Human Behavior, University of California, Irvine, CA, USA

The shape analysis of hippocampus was applied to evaluate the changes in developmental brain in 48 children from 6 to 9 years old. Three different methods are used, including the surface-to-centerline distance mapping and non-rigid registration using robust point mapping (RPM) and Demons algorithm. The differences between males and females were also analyzed. Although a significant difference was found in some scattered regions, the averaged difference between the two age or sex groups is very small. The results obtained using the distance mapping and RPM registration methods showed similar patterns. The observed differences are mostly likely coming from individual variations.