Delphine Ribes1,2, Bndicte Mortamet1, Meritxell Cuadra Bach3, Clifford R. Jack4, Reto Meuli5, Gunnar Krueger1, Alexis Roche1
1Advanced Clinical Imaging Technology, Siemens Medical Solutions-CIBM, Lausanne, Switzerland; 2Radiology, UNIL, Lausanne, Switzerland; 3Signal Processing Laboratory (LTS5), EPFL, Lausanne, Switzerland; 4Mayo Clin, Rochester, MN USA; 5Centre Hospitalier Universitaire Vaudois & University of Lausanne, Lausanne, Switzerland
Normal aging and numerous diseases such as Alzheimers disease (AD), vascular dementia (VD) and other neurodegenerative diseases lead to brain tissue changes over time. In the interest of disease classification and diagnosis, it is highly desirable to have reliable and automatic tools to measure brain tissue volumes. In this study, we compare volumetric and GM probabilities differences extracted from standard T1-weighted images using SPM8, VBM8 and an in-house automatic tissue classification algorithm called VEMTC.