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Abstract #0536

Using Multi-Parametric Quantitative MRI to Model Myelin in the Brain

J. B. M. Warntjes1,2, J. West1,3, O. Dahlqvist-Leinhard1,3, G. Helms4, A.-M. Landtblom5, P. Lundberg6,7

1Linkping University, Center for Medical Image Science & Visualization, Linkping, Sweden; 2Department of Medicine & Health, Division of Clinical Physiology, Linkping, Sweden; 3Department of Medicine & Health, Division of Radiation Physics, Linkping, Sweden; 4University Medical Center, MR-Research in Neurology & Psychiatry, Gttingen, Germany; 5Department of Clinical Neuroscience, Linkping, Sweden; 6Linkping University, Dept of Radiation Physics & Dept of Radiology, IMH, University of Linkoping, Linkping, Sweden; 7University Hospital of Linkping, Dept of Radiation Physics & Dept of Radiology, CKOC, University Hospital of Linkoping, Linkping, Sweden

A model is proposed where myelin partial volume in brain parenchyma is estimated utilizing quantitative Magnetic Resonance Imaging. QMRI aims at the absolute measurement of physical parameters such as the relaxation rates R1 and R2 and proton density PD. Data on 9 brain structures of 30 healthy subjects were used to set the model parameters. The model estimated an average 30.61.2% myelin in healthy white matter. Examples are shown for clinical cases were both general and local reductions of myelin can be observed.