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Abstract #0546

Acquisition of Spatially-registered Helium-3 & Proton 3D Image Sets of the Lung in Less than 10 Seconds using Compressed Sensing

Kun Qing1, Talissa A. Altes2, Nicholas J. Tustison2, Jaime F. Horta Coelho Mata2, Grady W. Miller2,3, Eduard E. De Lange2, William A. Tobias3, Gordon D. Cates3, James R. Brookeman2, John Philip Mugler1,2

1Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; 2Radiology, University of Virginia; 3Physics, University of Virginia

Random undersampling combined with compressed-sensing reconstruction permits acquisition of 3D helium-3 and proton data sets, with isotropic 3.9-mm spatial resolution, during a 7-second breath hold. The resulting image quality is very similar to that obtained using a fully-sampled acquisition that requires almost 20 seconds. This capability should be valuable for quantitative assessment of ventilation defects in diseases such as asthma, CF or COPD.