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Abstract #0549

Imaging of Lung Micromechanics with Hyperpolarized Gas Diffusion MRI: Regional Compliance

Yi Xin1, Kiarash Emami1, Stephen J. Kadlecek1, Puttisarn Mongkolwisetwara1, Nicholas N. Kuzma1, Harilla Profka1, Yinan Xu1, Hooman Hamedani1, Benjamin M. Pullinger1, Rajat K. Ghosh1, Jennia N. Rajaei1, Stephen Pickup1, Masaru Ishii2, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2OtolaryngologyHead & Neck Surgery, Johns Hopkins University, Baltimore, MD, USA

Measurements of 3He apparent diffusion coefficient as a function of lung inflation level reveal a more drastic relative increase in regional ADC values at lung pressures above 12 cmH2O in an elastase model of rat emphysema compared to the healthy animals. This altered ADC imaging protocol can potentially serve as a sensitive marker for changes in regional lung compliance induced by lung diseases such as emphysema.