Bastiaan Driehuys1,2, Zackary I. Cleveland2,3, John Nouls1,2, S. Sivaram Kaushik2,4, Gary P. Cofer2, Santiago Jimenez-Martinez1, Jan Wolber5, Monica Kraft6, H. Page McAdams1
1Department of Radiology, Duke University, Durham, NC, USA; 2Center for in vivo Microscopy, Duke University; 3Department of Radiology, Duke University, Durham, NC, USA; 4Biomedical Engineering, Duke University; 5GE Healthcare; 6Pulmonary and Critical Care Medicine, Duke University
As part of a recently completed phase I clinical trial, 44 subjects underwent hyperpolarized (HP) 129Xe ventilation imaging. Here we report quantitative analysis of these 129Xe ventilation images using a simple reader-based scoring system. We show that xenon ventilation scores correlate significantly with pulmonary function tests and readily separate subjects with chronic obstructive pulmonary disease (COPD) from age-matched controls. Moreover, in the healthy subject population, we show that defects scores correlate significantly with age, a finding that may suggest that 129Xe, with its high resistance to flow, is more sensitive to minor obstruction than 3He.