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Abstract #0573

Influence of Spectral Model & Signal Decay on Hepatic Fat Fraction Measurements at 3T with Dual-Echo Dixon Imaging

Holger Eggers1, Thomas G. Perkins2, Shahid M. Hussain3,4

1Philips Research, Hamburg, Germany; 2Philips Healthcare, Cleveland, OH, USA; 3University of Nebraska Medical Center, Omaha, NE, USA; 4The Nebraska Medical Center, Omaha, NE, USA

The accurate estimation of fat fractions in the liver with MRI is complicated by various effects, including signal modulation due to the spectral composition of fat and signal decay due to transverse relaxation. These effects have been addressed in multi-echo imaging by more complex signal models, exploiting the availability of more data for a robust fit. In this work, corrections applicable in dual-echo imaging are explored, with which similar quantitative results as with six-echo imaging may be obtained. Thus, fat fractions may be derived from routine clinical scans with higher spatial resolution and larger coverage in single breath-holds.