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Abstract #0579

Quantification of Susceptibility Mapping with Synchrotron X-ray Fluorescence Iron Mapping

Weili Zheng1, E Mark Haacke1, Saifeng Liu2, Jaladhar Neelavalli3, Helen Nichol4

1Radiology, Wayne State University, Detroit, MI, USA; 2School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; 3The Magnetic Resonance Imaging Institute for Biomedical Research, Detroit, MI, USA; 4Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Susceptibility weighted imaging (SWI) has been widely accepted as an in vivo neuroimaging technique for monitoring neurologic disorders with iron-related susceptibility changes. We assumed that ferritin was the dominant iron species in putamen and caudate and estimated the relationship between SWIM susceptibility and iron concentration, for the first time on a voxel by voxel basis. This provides a major advance in noninvasive and safe estimation of iron in human brain tissue in vivo using susceptibility mapping.