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Abstract #0580

Correlation between Elemental Distribution & Susceptibility Change in Intracerebral Hemorrhagic Stroke

Weili Zheng1, E. Mark Haacke1, Helen Nichol2

1Radiology, Wayne State University, Detroit, MI, USA; 2Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Both T2* weighted imaging (T2*WI) and susceptibility weighted imaging (SWI) are sensitive to local susceptibility change and widely used in similar clinical applications. Here, we introduced synchrotron Rapid Scanning X-ray Fluorescence (RS-XRF) to investigate how major elements are related to the susceptibility change in intracerebral hemorrhagic stroke (ICH) and how T2*WI and SWI represent it. We find SWIM is superior to T2* for imaging iron in hemorrhage and can differentiate Ca from Fe. SWIM and T2* map complement each other and can provide more specific and accurate spatial and chemical information in ICH and other Fe/Ca related susceptibility changes.