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Abstract #0659

Metabolic Imaging of the Rat Brain using Hyperpolarized [1-13C]Ketoisocaproate & [1-13C]Pyruvate

Sadia Asghar Butt1, Lise Vejby Sgaard1, Peter Magnusson1, Mette Lauritzen1, Per keson1, Jan Henrik Ardenkjr-Larsen2

1Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark; 2GE Healthcare, Broendby, Denmark

Metabolic imaging of hyperpolarized [1-13C]ketoisocaproate and [1-13C]pyruvate was performed in the normal rat brain. A chemical shift imaging (CSI) sequence was acquired after injection of [1-13C]ketoisocaproate or [1-13C]pyruvate. The metabolite CSI maps showing biodistribution of metabolites reveal that [1-13C]leucine (formed by transamination of injected [1-13C]ketoisocaproate) is located in the brain tissue.