Sadia Asghar Butt1, Lise Vejby Sgaard1, Peter Magnusson1, Mette Lauritzen1, Per keson1, Jan Henrik Ardenkjr-Larsen2
Research Centre for Magnetic Resonance,
Metabolic imaging of hyperpolarized [1-13C]ketoisocaproate and [1-13C]pyruvate was performed in the normal rat brain. A chemical shift imaging (CSI) sequence was acquired after injection of [1-13C]ketoisocaproate or [1-13C]pyruvate. The metabolite CSI maps showing biodistribution of metabolites reveal that [1-13C]leucine (formed by transamination of injected [1-13C]ketoisocaproate) is located in the brain tissue.