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Abstract #0666

Monitoring of Transplanted Pancreatic Islets in Humans By MRI

Daniel Jirak1, Frantisek Saudek2, Monika Dezortova1, Peter Girman2, Vit Herynek1, Jan Kriz2, Zuzana Berkova2, Klara Zacharovova2, Jan Peregrin1, Milan Hajek1

1Department of Diagnostic & Interventional Radiology, Institute for Clinical & Experimental Medicine, Prague, Czech Republic; 2Diabetes Center, Institute for Clinical & Experimental Medicine, Prague, Czech Republic

We tracked iron-labeled pancreatic islets in type-1 diabetic recipients and quantified the islet loss in liver tissue by MR imaging during 6 months after transplantation. Hypointense islet spots and their area in the liver were counted and outlined manually. Function of transplanted islets was confirmed by C-peptide production. A dramatic loss of hypointense spots occurred in the 1st week following the transplantation. Then the number of spots and their area stabilized. Our data suggest that post-transplant MR monitoring might be of importance for assessment of the islet fate following clinical transplantation.