Abstract #0678

Tractometry Comprehensive Multi-modal Quantitative Assessment of White Matter Along Specific Tracts

Sonya Bells¹, Mara Cercignani², Sean Deoni^3,4, Yaniv Assaf⁵, Ofer Pasternak⁶, C John Evans⁷, a Leemans⁸, Derek K. Jones⁷

¹CUBRIC , School of Psychology, Cardiff, United Kingdom; ²Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; ³School of Engineering, Brown University, Providence, RI, USA; ⁴Centre of Neuroimaging Sciences-Institute of Psychiatry, King's College, London, United Kingdom; ⁵Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel; ⁶Brigham & Women's Hospital, Harvard Medical School, Bostan, MA, USA; ⁷CUBRIC, School of Psychology, Cardiff, United Kingdom; ⁸Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

A new technique called tractometry is introduced. Tractometry is a comprehensive assessment of tract-specific microstructural measurements is introduced. This method combines macromolecular measurements from optimized magnetization transfer imaging, multicomponent T2 species from relaxometry and axon density measurements from CHARMED along speciﬁc white matter pathways reconstructed from diffusion MRI proving us with a comprehensive assessment of multiple microstructure metrics in a unique way. Importantly, we find little correlation between proxy indices of myelination and axonal morphology, suggesting that additional complementary WM microstructural information is obtained with our approach.