Fernando Calamante1,2, Jacques-Donald Tournier1,2, Robin M. Heidemann3, Alfred Anwander3, Graeme D. Jackson1,2, Alan Connelly1,2
1Brain Research Institute, Florey Neuroscience Institutes, Heidelberg West, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; 3Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany
Super-resolution track-density imaging (TDI) has been recently introduced as a means to achieve high-quality images, with very high spatial-resolution and anatomical contrast; the long-range information contained in the diffusion MRI fibre-tracks provides intra-voxel information to generate an image with higher resolution than that of the acquired source diffusion data. As with any new technique offering super-resolution, the question arises as to the validity of the extra information generated. We validate here the super-resolution property of the TDI method by using in vivo human 7T diffusion data, and in silico diffusion data from a well-characterised numerical phantom.