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Abstract #0676

Mapping Hubs in the Neocortical Structural Network of the Human Brain Shows Lateralization

Emil Harald Jeroen Nijhuis1,2, Anne-Marie van Cappellen van Walsum2,3, David G. Norris1,4

1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands; 2MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Netherlands; 3Department of Anatomy, Radboud University Nijmegen Medical Center, Netherlands; 4Erwin L Hahn Institute for MRI, Universitt Duisburg-Essen, Germany

Lateralization is a known phenomena in the human brain and has been described and investigated through various MR imaging techniques. This study provides to the best of our knowledge the first evidence through graph theoretical measures that neocortical hubs are lateralized. The presented research uses high angular resolution diffusion imaging (HARDI) data to reconstruct detailed neocortical networks with 1000 nodes/ROIs for a cohort of 46 young adults. Using graph theory and surface based analysis we identify hubs in the neocortical network. Our results show that critical hubs in the neocortex coincide with the default mode network and language processing areas.