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Abstract #0736

Direct Multi-Tissue Assessment of In Vivo Postprandial Lipid Handling in ZDF Rats using Localized 1H-[13C] MRS

Richard Jonkers1, Luc van Loon2, Klaas Nicolay1, Jeanine Prompers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Department of Human Movement Sciences, Maastricht University Medical Centre+, Maastricht, Netherlands

Insulin resistance and type 2 diabetes are associated with excessive lipid accumulation in liver and muscle. In this study, we investigated in vivo lipid handling in liver and muscle tissue of pre-diabetic and diabetic ZDF rats using localized 1H-[13C] MRS after administration of 13C-labeled lipids. In liver, lipid uptake was increased in both pre-diabetic and diabetic rats compared with controls. Lipid uptake in muscle was likewise increased in diabetic rats, but in contrast it was lower in pre-diabetic rats compared with controls. Whereas lipid utilization was largely unaffected in liver, it was impaired in muscle of pre-diabetic and diabetic rats.