Abstract #0742

Validation of Imaging Biomarkers of Steatosis in ob/ob Mice with Multiple SPIO Injections

Catherine D. G. Hines¹, Ian Rowland², Calista Roen¹, Diego Hernando¹, Debra Horng², Huanzhou Yu³, Jean Brittain⁴, Scott B. Reeder¹

¹Radiology, University of Wisconsin-Madison, Madison, WI, USA; ²Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; ³Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA; ⁴Global Applied Science Laboratory, GE Healthcare, Waukesha, WI, USA

Iron overload often occurs concurrently in chronic liver disease patients, confounding accurate liver fat quantification. Recent work has demonstrated the importance of T2* corrections for quantifying liver fat, using quantitative MRI imaging and spectroscopic methods. Consequently, this work validates the requirement for T2* corrections for fat quantification in an animal model of steatosis with increasing iron overload. In vivo results show this method is robust to increasing iron over a range of fat-fractions, T2* correction is necessary in the presence and absence of iron, and that MRI fat quantification is predictive of amount of stored triglycerides.