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Abstract #0770

The Ratio of CBF to CMRO2 Change with Brain Activation Remains Unchanged between Simple & Complex Stimuli in the Human Visual Cortex

Valerie Griffeth1, Richard Buxton2

1Department of Bioengineering, UC San Diego, La Jolla, CA, USA; 2Department of Radiology, UC San Diego, La Jolla, CA, USA

We applied a calibrated-BOLD methodology to compare the effects of a simple flickering checkerboard stimulus to that of a complex movie stimulus on the coupling of CBF and CMRO2 responses in the human visual cortex. We found no significant difference in the coupling between the movie stimulus and two flickering checkerboard contrast levels of 10% and 40%. Furthermore, the BOLD, CBF and CMRO2 responses to these two contrast levels appear to bracket the physiologic response to the complex movie stimulus.