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Abstract #0771

Calibration & Validation of TRUST MRI for the Estimation of Cerebral Blood Oxygenation

Hanzhang Lu1, Feng Xu1, Ksenija Grgac2,3, Peiying Liu1, Qin Qin2,3, Peter van Zijl2,3

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; 3F.M. Kirby Center, Kennedy Krieger Institute, Baltimore, MD, USA

Recently, a T2-Relaxation-Under-Spin-Tagging (TRUST) MRI technique was developed to quantitatively estimate blood oxygenation (Y) via the measurement of pure blood T2. However, a human validation study has not been conducted. Here we used in vitro blood experiments to determine a 3-dimentional calibration plot in which blood T2 is a function of both Y and Hct. We further showed that, during hypoxia, Ya measured with PulsOx was 84.03.6% (N=7), while Ya derived from TRUST blood T2 and in vitro calibration plot was 83.73.6%. Furthermore, a significant correlation was observed between these two measures across subjects (P=0.05).