Thomas David Reed1, Rashmi Agni2, Catherine Hines1, Richard Bruce1, Mona Ranade1, Benjamin Soriano3, Kiyarash Mohajer1, Scott B. Reeder1
1Radiology, University of Wisconsin, Madison, WI, United States; 2Pathology, University of Wisconsin, Madison , WI, United States; 3Pathology, University of Wisconsin, Madison, WI, United States
Over the last several years, quantitative MR methods for accurate measurement of hepatic steatosis have been developed. The majority of studies validated quantitative MR methods using single voxel MRS as the reference standard. These methods have demonstrated excellent correlation and agreement between proton density fat-fraction and MRS so long as all confounding factors (eg. T1, T2*, spectral complexity of fat, noise bias and eddy current correction) are addressed. However, there is a paucity of tissue validation in these studies. In this retrospective study involving 26 patients, we demonstrate good correlation (r2=0.77) between MRI fat-fraction and histological grading of steatosis.