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Abstract #0891

Hyperpolarized Helium Measurements of PAO2 Correlate with Neutrophil Inflammation in the Rat Bleomycin Model

Puttisarn Mongkolwisetwara1, Evguenia Borissova Arguiri2, Kiarash Emami1, Yi Xin1, Nicholas N. Kuzma1, Stephen J. Kadlecek1, Yinan Xu1, Harilla Profka1, Melpo Christofidou-Solomidou2, Milton D Rossman2, Masaru Ishii3, Rahim R. Rizi

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Pulmonary Division, University of Pennsylvania, Philadelphia, PA, United States; 3OtolaryngologyHead & Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

Idiopathic Pulmonary Fibrosis (IPF) is a relatively rare and most debilitating disease due to the fact that it is a progressive disorder whose pathogenesis is still unknown. Therefore, determining the causes of IPF and finding a probe to monitor potential treatments are essential goals of this study. The pulmonary function measurement by 3He MRI is a sensitive tool in assessing lung microstructure and function. Significant changes in all parameters of alveolar partial pressure, ADC, and fractional ventilation confirm that we can employ 3He MRI to gauge microstructure (ADC changes), lung function (Fractional Ventilation) and deficient in O2 uptake in alveolar walls (PaO2).