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Abstract #0892

Quantitative Assessment of Chronic Exposure to Cigarette Smoke in Mouse Lungs by Hyperpolarized Gas MRI

Yi Xin1, Kiarash Emami1, Stephen J. Kadlecek1, Puttisarn Mongkolwisetwara1, Nicholas N. Kuzma1, Harilla Profka1, Yinan Xu1, Hooman Hamedani1, Benjamin M. Pullinger1, Rajat K. Ghosh1, Jennia N. Rajaei1, Stephen Pickup1, Masaru Ishii2, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2OtolaryngologyHead & Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

We present measurements of lung microstructure using 3He Apparent Diffusion Coefficient (ADC) and Ventilation in smoked mice. After six months of smoke exposure, the smoke-exposed group has significantly larger ADC values, while the ventilation maps are visually and quantitatively unchanged. We conclude that this smoked mice model more closely resembles the disease model in human emphysematous rather than human chronic bronchitic disease.