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Abstract #0916

Finite Element Simulations of 129Xe Gas Diffusion in Models of Lung Airways

Juan Parra-Robles1, Steven R. Parnell1, Salma Ajraoui1, Xiaojun Xu1, Jim M. Wild1

1Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Due to their different diffusivities , 3 and 129Xe are sensitive to different length scales of acinar structure. In this work, we investigate short-range 129Xe diffusion in a model of acinar airways using finite element computer simulations. The results suggest that 129Xe short range diffusion experiments may be more sensitive to alveolar structure than 3He, while being less sensitive to branching effects. This may simplify the development of 129Xe-based MR lung morphometry techniques, which could be based on a two compartment model.