Juan Parra-Robles1, Steven R. Parnell1, Salma Ajraoui1, Xiaojun Xu1, Jim M. Wild1
Due to their different diffusivities , 3 and 129Xe are sensitive to different length scales of acinar structure. In this work, we investigate short-range 129Xe diffusion in a model of acinar airways using finite element computer simulations. The results suggest that 129Xe short range diffusion experiments may be more sensitive to alveolar structure than 3He, while being less sensitive to branching effects. This may simplify the development of 129Xe-based MR lung morphometry techniques, which could be based on a two compartment model.