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Abstract #0917

Finite Element Simulations of Short-Range 3He Diffusion in a Model of Branching Acinar Airways: Implications for In Vivo Lung Morphmetry

Juan Parra-Robles1, Steven R. Parnell1, Salma Ajraoui1, Xiaojun Xu1, Jim M. Wild1

1Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

In this work, we use finite element simulations of diffusion in a model of branching alveolar ducts to investigate in detail the effects of acinar branching structure on short-range 3He diffusion measurements. The obtained results indicate that branching effects have significant influence in 3He diffusivity, even at short diffusion times. The cylinder model theory do not account for significant dependences upon diffusion time, branching geometry and airway length; and further development and validation is required.