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Abstract #0931

An Improved Scheme for a Robust High Resolution Measurement of Alveolar Oxygen Tension in Human Lungs

Hooman Hamedani1, Kiarash Emami1, Stephen J. Kadlecek1, Yinan Xu1, Yi Xin1, Amy Barulic1, Puttisarn Mongkolwisetwara1, Nicholas N. Kuzma1, Peter Magnusson2, Lise Vejby Sgaard2, Sandra Diaz3, Per keson2, G. Wilson Miller4, Milton D. Rossman5, G. Wilson Miller6, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 3Department of Clinical Sciences, Malm University Hospital, Malm, Sweden; 4Radiology, University of Virginia, Charlottesville, VA, United States; 5Pulmonary, Allergy & Critical Care Division, University of Pennsylvania, Philadelphia, PA, United States; 6Department of Radiology, University of Virginia School of Medicine, Charlottesville, VA

A new higher-resolution multi-slice scheme for measuring regional partial pressure of oxygen in the lungs via HP 3He MRI is presented. This new scheme is based on eliminating the delay time needed to differentiate the effects of oxygen and RF pulses, instead making use of two interleaved back-to-back acquisitions for each slice. The resulting PAO2 errors are decreased by a factor of ~3 in this new scheme.