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Abstract #0932

Imaging Regional Heterogeneity of Pulmonary Oxygen Tension as a Diagnostic Tool for Obstructive Lung Diseases

Yinan Xu1, Hooman Hamedani1, Kiarash Emami1, Stephen J. Kadlecek1, Yi Xin1, Puttisarn Mongkolwisetwara1, Amy Barulic1, Nicholas N. Kuzma1, Peter Magnusson2, Lise Vejby Sgaard2, Sandra Diaz3, Wilson Miller4, Milton D. Rossman5, Masaru Ishii6, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 3Department of Clinical Sciences, Malm University Hospital, Malm, Sweden; 4Department of Radiology, University of Virginia, Charlottesville, VA, United States; 5Pulmonary, Allergy & Critical Care Division, University of Pennsylvania, Philadelphia, PA, United States; 6OtolaryngologyHead & Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

New method for quantifying the lung heterogeneity from the HP 3He MRI measurements of alveolar partial oxygen pressure pO2 is tested in this human study. The method allows us to differentiate healthy smokers and COPD patients from non-smokers based on the difference in their lung homogeneity.